منابع مشابه
L-dopa
Oleh Hornykiewicz was born in 1926 in Sykhiw, Poland (now Ukraine). In 1951, he received his M.D. degree from the University of Vienna and joined the faculty of his alma mater the same year and has worked there ever since. He also served for twenty years as chairman of the Institute of Biochemical Pharmacology. In 1967, he began a long association with the University of Toronto in Canada and, i...
متن کاملL-Dopa and Behavior
to include the "why" of procedures, but rather presents step-by-step instructions and recipes for the bench technologist. The first of the three sections deals with biochemical identification tests, from acetate utilization to Voges-Proskauer. Each includes descriptions of purpose, principle, mechanisms, equipment and reagents, method, and interpretation. The format is short, lucid, and informa...
متن کاملHypotension caused by L-dopa.
In 20 patients with idiopathic Parkinsonism maximum tolerated doses of L-dopa were found to induce a mean reduction in blood pressure (erect systolic) of 19.3 mm.Hg, without any significant change in pulse rate. This hypotension may be due to dopamine, acting on adrenergic nerve endings or on the central nervous system itself.
متن کاملl-Dopa induced dyskinesias in Parkinsonian mice: Disease severity or l-Dopa history
In Parkinson's disease, the efficacy of l-Dopa treatment changes over time, as dyskinesias emerge with previously beneficial doses. Using MitoPark mice, that models mitochondrial failure in dopamine (DA) neurons and mimics the progressive loss of dopamine observed in Parkinson's disease, we found that the severity of DA denervation and associated adaptations in striatal neurotransmission at the...
متن کاملL-dopa therapy in Parkinson's disease.
The gait of normal subjects was examined electromyographically and the pattern was altered during preferential blockade of large nerve fibres to alternating activity in flexor and extensor muscles. The EMG activity was disrupted more in flexor than extensor muscles by preferential ischaemic blockade. Normal gait was associated with flexor contraction only when the foot was lifted and placed on ...
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ژورنال
عنوان ژورنال: Journal of Parkinson's Disease
سال: 2017
ISSN: 1877-7171,1877-718X
DOI: 10.3233/jpd-179004